Biography

About me

I am very interested by research projects on the dynamic of 3D gemonic material folding and organization. Exploring the inter-correlations in between the chromatin folding and gene expression level and regulation sparked my interest. If DNA is well-known for containing the genetic code essential to the cell physiology, its mechanical characteristics are now also under close study as they may actively participate to the different biological processes. Studying the spatial architecture and dynamics of the genomic material, from the wrapping of the double helix around histones to the folding and the packaging of the DNA molecule, compose an important field of research to fully understand of genome conformation and function.
I truly believe collaborating in an interdisciplinary way and combining computational model and experimental data will allow a better understanding of how chromosomes fold, interact and induce the transcriptional gene activity.

Vitae

Training and Diploma

Research Assistant
Department: Molecular Medicin
Institut: Basic Medical Sciences
Univeristy of Oslo
Oslo, Norway (2016-Now)
  • Lamina-associated domains as tuning actors configuring the mechanical constraints of the chromatin domain at nuclear periphery in a circadian system context
    - Establishing whether lamin B1 lamina-associated domains (LADs) act as preferential actors that modulate mechanical constraints and physical properties of the inter-LAD chromatin fiber, and thereby dynamically contribute to regulating gene expression in these regions in a circadian system context
    - Performing a kinetic Monte-Carlo Simulations based on a mesoscopic statistical model of chromatin
    - Analyzing genome wide RNASeq and ChiPSeq data to investigate how cycling expression pattern of metabolic genes is relates to a oscillating recruitment of LADs
    - Improving a computational procedure for the analysis of the large ChipSeq data : EDD peakcalle

    Team: Collas P.

    Univeristy of Oslo
    CollasLab

    Oslo, Norway
PhD in BioPhysic (Defense: 16th Oct. 2015)
Doctoral School: Matter of Science,
Specialty: Physique
Univeristy of Toulouse III
Toulouse, France (2012-2015)
  • Study at the single molecule level of conformational changes of the DNA molecule: impact of local defects included in the DNA molecule and of physicochemical conditions set by the solvent
    - Measure the impact of intrinsic bending, local denaturation or variation of ion concentration in solution on the DNA conformations with high-throughput Tethered Particle Motion (HT-TPM)
    - Perform a kinetic Monte-Carlo Simulation based on a mesoscopic statistical model of DNA
    - Develop a computational procedure for the analysis of the large data set from HT-TPM

    Advisor: Destainville N. (LPT) and Tardin C. (IPBS)

    Univeristy of Toulouse III
    Laboratoires LPT and IPBS, CNRS

    Toulouse, France
Master 2R, Specialty: Nanosciences, Nanomesures
Univeristy of Toulouse III, (France)
2011-2012

  • Master's training period in nanotechnologies (6 months)
    Formation of nano-energetic material made of Al/CuO alloy driven by DNA auto-assembly and chip integration
    - Construct heterogeneous advances material structured on 1D, 2D or 3D-dimensions by using the complementarity of the double strand DNA, and optimize its stability and its energetic response

    Advisor: Bancaud A. and Rossi C.

    LAAS-CNRS
    Toulouse, France
Master 1, Specialty: Fundamental Physic
University of Toulouse III, (France) 2010-2011
  • Master's training period in microscopy (2 months)
    Studies of the 2-(3-perylene) ethanoic acid molecular by Scanning Tunneling Microscopy (STM) at Low Temperature and Ultra High Vacuum
    - Measure the value of the single negative charge appearing during the process

    Advisor: Coratger R.

    CEMES-CNRS
    Toulouse, France
Licence 3, Specialty: Physics et Applications
University of Toulouse III (France)
2009-2010
  • Training period at the Braley company
    Realization of a solar furnace coupled with a Stirling engine
    - Realize the solar furnace and animate a stand on the energies at the open day of the company
  • Braley Company
    Bozouls, France

Congresses and Thematics Schools

Oral Communication
  • 3rd meeting of FRBT
    Toulouse, France
    November 2014
  • Seminar IRSAMC
    Toulouse, France
    January 2014
  • 3rd edition of the “Les Houches School” in computational physics: DNA, from molecules to evolution
    Les Houches, France
    May 2013
Thematic School
  • Summer school: SOFT-FIRE-2014
    Cargèse, France
    August 2014 (2 weeks)
  • 3rd edition of the “Les Houches School” in computational physics: DNA, from molecules to evolution
    Les Houches, France
    May 2013
Poster Communication
  • Gordon Research Conference and Seminar (GRC and GRS): Soft Condensed Matter Physics
    New London, USA
    8-14 Aout 2015
  • Summer school: SOFT-FIRE-2014
    Cargèse, France
    August 2014
  • GDR Cell Tiss 2013
    Lyon, France
    May 2013
  • 3rd edition of the “Les Houches School” in computational physics: DNA, from molecules to evolution
    Les Houches, France
    May 2013

Student Supervision

Master's training period:
Juliette Wilhem
  • Probing the experimental effect of the ionic strength on the DNA conformation release by TPM, at the single molecule level
    Summer 2014 (2 months)

Other Activities and Interests

Other professional experience
  • Technique staff at the Symposium J de l’E-MRS 2012 Spring Meeting
    Strasbourg, France (2012)
Associative activities
  • Co-founder and editor of the inter-university newspaper: "Le Lapin Blanc"
    University of Toulouse I, II and III
    France (Since 2009)
  • University of Toulouse III site organizer for the AMIDONS association
    Association Inter- university for donation of blood
    University of Toulouse III
    2007-2008, France
  • AMIDONS association volunteer
    Since 2006, Toulouse France
  • First aid qualification
    Attestation de Formation aux Premiers Secours
    Œuvre hospitalière française de l’ordre de Malte
    2003, France
Entertainment
  • Reading (Polar, Heroic fantasy, Anticipation), climbing, volleyball, badminton, cinema, theater, rugby

References

  • Pr. Destainville Nicolas
    Laboratoire de Physique Théorique,
    Team: Physique Statistique des Systèmes Complexes
    Toulouse, France
    Tel: +33 (0)5 61 55 60 48
    e-mail: nicolas.destainville@irsamc.ups-tlse.fr
  • Dr. Tardin Catherine
    Institut de Pharmacologie et de Biologie Structurale,
    Team: Membrane and DNA dynamics
    Toulouse, France
    Tel: +33 (0)5 61 17 54 68
    e-mail: catherine.tardin@ipbs.fr
  • Dr. Salomé Laurence
    Institut de Pharmacologie et de Biologie Structurale,
    Team: Membrane and DNA dynamics
    Toulouse, France
    Tel: +33 (0)5 61 17 59 39
    e-mail: laurence.salome@ipbs.fr
  • Dr. Bancaud Aurélien
    Laboratoire d'analyse et d'architecture des systèmes,
    Team: Nano Ingénierie et Intégration des Systèmes
    Toulouse, France
    Tel: +33 (0)5 61 33 62 46
    e-mail: abancaud@laas.fr
  • Pr. Allemand Jean-Francois
    Laboratoire de Physique Statistique,,
    Team: P
    Paris, France
    Tel: +33 (0)1 44 32 34 92/33 61
    e-mail: Jean-Francois.Allemand@lps.ens.fr
  • Dr. Lesne Annick
    Laboratoire de physique théorique de la matière condensée,
    Team: M
    Paris, France
    Tel: +33 (0)5 61 17 59 39
    e-mail: lesne@lptmc.jussieu.fr
  • Pr. Collas Philippe
    Basic Medical Sciences Inst., Dep. of Molecular Medicine,
    Team: CollasLab
    Oslo, Norway
    Tel: +47 (0)2 28 51 060
    e-mail: philippe.collas@medisin.uio.no






If you would like more information here it is my CV